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Diabetes mellitus type 2, as monotherapy or in combination with sulfonamides derivatives, metformin, or insulin in the absence of the effect of diet therapy, exercise, and monotherapy with one of the above funds.
Special notes: hypoglycaemic agent’s thiazolidinediones series for oral use. By reducing insulin resistance, increases the consumption of glucose and insulin reduces the release of glucose from the liver.
Dosage: Inside, 1 time per day (regardless of the meal). Monotherapy: 15-30 mg, if necessary, the dose may be increased stepwise to 45 mg / therapy: derivatives of sulfonylurea, metformin, pioglitazone treatment begins with taking 15 mg or 30 mg (in case of hypoglycemia reduce the dose of sulfonylureas or metformin). Treatment in combination with insulin: the initial dose to 15 to 30 mg / day, insulin dose remained the same or be reduced by 10-25% (if the patient reports hypoglycemia or glucose concentration in plasma is reduced to less than 100 mg / dl).
Contraindications: Hypersensitivity, diabetes mellitus type 1, diabetic ketoacidosis, liver disease in the acute stage, ALT level, exceeding the norm in 2,5 times, pregnancy, breast-feeding.
Side effects: hypoglycemia, edema (4.8% of cases with monotherapy and 15.3% in combination with insulin), anemia (in 1-1,6% of cases), reduced levels of bilirubin, AST, ALT, alkaline phosphatase and gamma-glutamyltransferase.
Guidance for children and pregnant women: Time of treatment should stop breast vskarmlivanie.Vozrast to 18 years (safety and efficacy in this age group of patients not identified).
Cautions: With care given to patients with edema and moderate increases in levels of enzymes. Hypoglycemia during combination therapy requires dose reduction associated sulfonamides or insulin. Against a background of renal insufficiency does not require correction dozy.Pri occurrence of jaundice treatment. Patients with anovulatory cycle in premenopauznom period of admission may cause ovulation and increase the risk of pregnancy (need for adequate contraceptive measures). Treatment should be undertaken in conjunction with diet therapy and exercise, under the control of the level of glycated hemoglobin.
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