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Buy glipizide (GLUCOTROL)
Substance (INN), glipizide (Glipizide)
Application: Diabetes mellitus type 2 in the absence of the effect of low-calorie diet, adequate exercise, etc.; diabetic microangiopathy.
Contraindications: Hypersensitivity, diabetic ketoacidosis, diabetic coma, juvenile diabetes type 1, fever, trauma, surgical interventions, pregnancy, breast-feeding.
Restrictions apply to: Diseases of the digestive tract, liver and kidneys (continuous monitoring of blood glucose levels), children’s age (efficacy and safety of children has not been established).
Application of pregnancy and breastfeeding: Contraindicated. In the case of pregnancy is required for cancellation 1 month before the expected birth and the transition to insulin therapy. At the time of treatment should stop breastfeeding.
Side effects: For a slow form of glipizide:
From the nervous system and sensory organs: dizziness, headache, insomnia, drowsiness, anxiety, depression, confusion, gait disturbance, paresthesia, hypersthesia, blurred vision, eye pain, conjunctivitis, bleeding in the retina.
Since the cardiovascular system and blood (hematopoiesis, hemostasis): syncope, arrhythmia, hypertension, feeling the tides.
From the Metabolic: hypoglycemia.
On the part of the digestive tract: anorexia, nausea, vomiting, feeling of heaviness in the epigastrium, indigestion, constipation, an admixture of blood in the stool.
For the skin: rash, urticaria, pruritus.
From the respiratory system: rhinitis, pharyngitis, dyspnea.
The part of the urogenital system: dysuria, lower libido.
Other: thirst, tremor, peripheral edema, non-localized pain throughout the body, arthralgia, myalgia, convulsions, sweating.
For quick form glipizide:
From the nervous system and sense organs: headache, dizziness, drowsiness.
Since the cardiovascular system and blood (hematopoiesis, hemostasis: leukopenia, agranulocytosis, thrombocytopenia, pancytopenia, hemolytic or aplastic anemia.
On the part of metabolism: diabetes insipidus, hyponatremia, porphyrin disease.
On the part of the digestive tract: nausea, vomiting, pain in the epigastrium, constipation, cholestatic hepatitis (yellow coloring of skin and sclera, discoloration of stool and dark urine, pain in the right hypochondrium).
For the skin: erythema, maculopapular rash, urticaria, photosensitivity.
Other: increased concentrations of LDH, alkaline phosphatase, and indirect bilirubin.
Interaction: Efficiency weaken the mineral-and glucocorticoids, amphetamines, anticonvulsants (hydantoin derivatives), asparaginase, baclofen, calcium antagonists, carbonic anhydrase inhibitors (acetazolamide), chlorthalidone, oral contraceptives, epinephrine, ethacrynic acid, furosemide, glucagon, salicylates, thiazide diuretics, thyroid hormones, triamterene, and other drugs that cause hyperglycemia. Anabolic steroids and androgens increase the hypoglycemic activity. Indirect anticoagulants, NSAIDs, chloramphenicol, klofibrat, guanetidin, MAO inhibitors, probenecid, sulfonamides, rifampin increase the concentration of free fraction in blood (due to displacement from its association with plasma proteins) and accelerate the biotransformation. Ketonazol, miconazole, sulfinpirazon block inactivation and exacerbate hypoglycemia. Against the background of alcohol may develop disulfiramopodobnogo syndrome (abdominal pain, nausea, vomiting, headache). Antithyroid and myelotoxic drugs increases the risk of agranulocytosis; recent addition – thrombocytopenia.
Overdose: Symptoms: hypoglycemia.
Treatment: removal of preparation, method of glucose and / or modification of diet in buy glipizide the mandatory monitoring of blood glucose levels, with severe hypoglycemia (coma, epileptiform seizures) – immediate hospitalization, the introduction of 50% glucose solution w / jet with simultaneous how does glipizide work infusion (in / drip) 10 % glucose solution to ensure that blood glucose concentration above 5.5 mmol / l, blood glucose monitoring is required for about 1-2 days after the patient from a coma. Dialysis is ineffective.
Dosing and Administration: inside before or during meals. High-speed form – 5 mg before breakfast, with no effect in a few days increase the dose of 2,5-5 mg (mandatory continuous monitoring of glucose concentration in the blood), maximum single dose – 15 mg, the maximum daily dose – 40 mg. Doses above 15 mg is prescribed in divided doses. Against the background of liver disease, kidney and elderly patients – 2,5 mg. A slow form – 5 mg at breakfast. To monitor the effectiveness of slow-form 1 time in 3 months determine the level of glycated hemoglobin. If after 3 months the effect is insufficient, the dose was increased to 10 mg or 20 mg (maximum daily dose).
Precautions: Precautions glipizide versus prandin for diabetes appoint elderly, debilitated and malnourished patients and patients with adrenal and pituitary insufficiency (to avoid hypoglycemic reactions and initial maintenance dose should not be high).