Buy glipizide (GLUCOTROL)

Substance (INN), glipizide (Glipizide)
Application: Diabetes mellitus type 2 in the absence of the effect of low-calorie diet, adequate exercise, etc.; diabetic microangiopathy.

Contraindications: Hypersensitivity, diabetic ketoacidosis, diabetic coma, juvenile diabetes type 1, fever, trauma, surgical interventions, pregnancy, breast-feeding.

Restrictions apply to: Diseases of the digestive tract, liver and kidneys (continuous monitoring of blood glucose levels), children’s age (efficacy and safety of children has not been established).

Application of pregnancy and breastfeeding: Contraindicated. In the case of pregnancy is required for cancellation 1 month before the expected birth and the transition to insulin therapy. At the time of treatment should stop breastfeeding.

Side effects: For a slow form of glipizide:
From the nervous system and sensory organs: dizziness, headache, insomnia, drowsiness, anxiety, depression, confusion, gait disturbance, paresthesia, hypersthesia, blurred vision, eye pain, conjunctivitis, bleeding in the retina.
Since the cardiovascular system and blood (hematopoiesis, hemostasis): syncope, arrhythmia, hypertension, feeling the tides.
From the Metabolic: hypoglycemia.
On the part of the digestive tract: anorexia, nausea, vomiting, feeling of heaviness in the epigastrium, indigestion, constipation, an admixture of blood in the stool.
For the skin: rash, urticaria, pruritus.
From the respiratory system: rhinitis, pharyngitis, dyspnea.
The part of the urogenital system: dysuria, lower libido.
Other: thirst, tremor, peripheral edema, non-localized pain throughout the body, arthralgia, myalgia, convulsions, sweating.
For quick form glipizide:
From the nervous system and sense organs: headache, dizziness, drowsiness.
Since the cardiovascular system and blood (hematopoiesis, hemostasis: leukopenia, agranulocytosis, thrombocytopenia, pancytopenia, hemolytic or aplastic anemia.
On the part of metabolism: diabetes insipidus, hyponatremia, porphyrin disease.
On the part of the digestive tract: nausea, vomiting, pain in the epigastrium, constipation, cholestatic hepatitis (yellow coloring of skin and sclera, discoloration of stool and dark urine, pain in the right hypochondrium).
For the skin: erythema, maculopapular rash, urticaria, photosensitivity.
Other: increased concentrations of LDH, alkaline phosphatase, and indirect bilirubin.

Interaction: Efficiency weaken the mineral-and glucocorticoids, amphetamines, anticonvulsants (hydantoin derivatives), asparaginase, baclofen, calcium antagonists, carbonic anhydrase inhibitors (acetazolamide), chlorthalidone, oral contraceptives, epinephrine, ethacrynic acid, furosemide, glucagon, salicylates, thiazide diuretics, thyroid hormones, triamterene, and other drugs that cause hyperglycemia. Anabolic steroids and androgens increase the hypoglycemic activity. Indirect anticoagulants, NSAIDs, chloramphenicol, klofibrat, guanetidin, MAO inhibitors, probenecid, sulfonamides, rifampin increase the concentration of free fraction in blood (due to displacement from its association with plasma proteins) and accelerate the biotransformation. Ketonazol, miconazole, sulfinpirazon block inactivation and exacerbate hypoglycemia. Against the background of alcohol may develop disulfiramopodobnogo syndrome (abdominal pain, nausea, vomiting, headache). Antithyroid and myelotoxic drugs increases the risk of agranulocytosis; recent addition – thrombocytopenia.

Overdose: Symptoms: hypoglycemia.
Treatment: removal of preparation, method of glucose and / or modification of diet in buy glipizide the mandatory monitoring of blood glucose levels, with severe hypoglycemia (coma, epileptiform seizures) – immediate hospitalization, the introduction of 50% glucose solution w / jet with simultaneous how does glipizide work infusion (in / drip) 10 % glucose solution to ensure that blood glucose concentration above 5.5 mmol / l, blood glucose monitoring is required for about 1-2 days after the patient from a coma. Dialysis is ineffective.

Dosing and Administration: inside before or during meals. High-speed form – 5 mg before breakfast, with no effect in a few days increase the dose of 2,5-5 mg (mandatory continuous monitoring of glucose concentration in the blood), maximum single dose – 15 mg, the maximum daily dose – 40 mg. Doses above 15 mg is prescribed in divided doses. Against the background of liver disease, kidney and elderly patients – 2,5 mg. A slow form – 5 mg at breakfast. To monitor the effectiveness of slow-form 1 time in 3 months determine the level of glycated hemoglobin. If after 3 months the effect is insufficient, the dose was increased to 10 mg or 20 mg (maximum daily dose).

Precautions: Precautions glipizide versus prandin for diabetes appoint elderly, debilitated and malnourished patients and patients with adrenal and pituitary insufficiency (to avoid hypoglycemic reactions and initial maintenance dose should not be high).

Actos generic

Diabetes mellitus type 2, as monotherapy or in combination with sulfonamides derivatives, metformin, or insulin in the absence of the effect of diet therapy, exercise, and monotherapy with one of the above funds.
Special notes: hypoglycaemic agent’s thiazolidinediones series for oral use. By reducing insulin resistance, increases the consumption of glucose and insulin reduces the release of glucose from the liver.
Dosage: Inside, 1 time per day (regardless of the meal). Monotherapy: 15-30 mg, if necessary, the dose may be increased stepwise to 45 mg / therapy: derivatives of sulfonylurea, metformin, pioglitazone treatment begins with taking 15 mg or 30 mg (in case of hypoglycemia reduce the dose of sulfonylureas or metformin). Treatment in combination with insulin: the initial dose to 15 to 30 mg / day, insulin dose remained the same or be reduced by 10-25% (if the patient reports hypoglycemia or glucose concentration in plasma is reduced to less than 100 mg / dl).
Contraindications: Hypersensitivity, diabetes mellitus type 1, diabetic ketoacidosis, liver disease in the acute stage, ALT level, exceeding the norm in 2,5 times, pregnancy, breast-feeding.
Side effects: hypoglycemia, edema (4.8% of cases with monotherapy and 15.3% in combination with insulin), anemia (in 1-1,6% of cases), reduced levels of bilirubin, AST, ALT, alkaline phosphatase and gamma-glutamyltransferase.
Guidance for children and pregnant women: Time of treatment should stop breast vskarmlivanie.Vozrast to 18 years (safety and efficacy in this age group of patients not identified).
Cautions: With care given to patients with edema and moderate increases in levels of enzymes. Hypoglycemia during combination therapy requires dose reduction associated sulfonamides or insulin. Against a background of renal insufficiency does not require correction dozy.Pri occurrence of jaundice treatment. Patients with anovulatory cycle in premenopauznom period of admission may cause ovulation and increase the risk of pregnancy (need for adequate contraceptive measures). Treatment should be undertaken in conjunction with diet therapy and exercise, under the control of the level of glycated hemoglobin.