|
America's online pharmacy serving your needs for no prescriptions Your right decision! Click Here ... |
Buy mestinon
Mestinon
International name:
Pyridostigmine bromide (Pyridostigmine bromide)
Group Affiliation:
Anticholinesterase means
Description of the active substance (INN):
Pyridostigmine
Dosage form:
injection, tablets
Pharmacological Effects:
Anticholinesterase means; has holinostimuliruyuschee effect through reversible inhibition of acetylcholinesterase and increased action of acetylcholine. It improves the neuromuscular transmission, increases the motility of the gastrointestinal tract, increases the tone of the bladder, bronchus, secretion of exocrine glands, causing bradycardia, causes a slight miosis, spasm of accommodation.
Indications:
Myasthenia, myasthenic syndrome, post-operative intestinal atony, atonic constipation, bladder atony, post-traumatic motor disturbances, flaccid paralysis, residual effects of polio, encephalitis violations emptying the bladder after gynecological operations and childbirth, termination miorelaxation with general anesthesia, an overdose of non-depolarizing muscle relaxant; intoxication anticholinergic LAN (with the prevalence of peripheral symptoms).
Contraindications:
Hypersensitivity, prior to receiving depolarizing muscle relaxants (suxamethonium, dekametony), iritis, COPD, bronchial asthma, obstructive ileus, gastrointestinal spasm organs, biliary and urinary tracts, myotonia, parkinsonism, thyrotoxicosis, postoperative shock crises, period laktatsii.C caution. Hypotension, heart failure, acute myocardial infarction, peptic ulcer and 12 duodenal ulcer, bradycardia, diabetes mellitus, gastrointestinal surgery, pregnancy.
Side effects:
Nausea, vomiting, diarrhea, stomach cramps, increased peristalsis, hypersecretion of bronchial glands, excessive salivation, lacrimation, increased urination, decreased blood pressure, bradycardia, miosis, convulsions, muscle twitching, myasthenia gravis. Skin rash (determined by the content in the preparation of bromine). Overdosage. Symptoms: increased secretion of lacrimal, salivary and sweat glands, skin hyperemia, severe weakness, blurred vision, miosis, dizziness, nausea, vomiting, involuntary defecation and urination, intestinal colic, bronchospasm, pulmonary edema, expressed or increasing myasthenia, paralysis of respiratory muscles, decrease blood pressure, collapse, bradycardia, a paradoxical tachycardia or cardiac arrest. Treatment: in / slow atropine sulfate – 1.2 mg (if needed – again after 2-4 hours, depending on heart rate), to restore and maintain vital body functions.
Dosage and administration:
Inside, in / m / w, p / k. When intestinal atony, atonic constipation – oral, 60 mg with an interval of 4 h, acute myasthenia gravis – by 60-180 mg 2-4 times a day if necessary, increase the dose. Parenteral (n / a, in / m / w) – 5 mg up to 5 times a day. To stop miorelaxation – in / in slowly, 5 mg, sometimes in combination with 0.5 mg of atropine. In some cases, these doses are distributed on 2 of the introduction. When anticholinergic poisoning BOS – w / slow or / m, with 3-5 mg.
Cautions:
It is recommended to choose the time of receipt Thus, to its maximum effect coincided with a period of physical activity of the patient. The lack of expected response to treatment may be due to an overdose. In the period of treatment should refrain from the use of ethanol. In the period of treatment must be careful when driving vehicles and occupation of other potentially hazardous activities that require high concentration of attention and quickness of psychomotor reactions.
Interaction:
Atropine weakens the effect (relative bradycardia, hypersecretion). Enhances the effect of depolarizing muscle relaxant, derivatives morphine and barbiturates. Incompatible with ethanol. M-holinoblokatory, ganglioplegic, quinidine, procainamide, local anesthetics, tricyclic antidepressants, antiepileptic and anti-LS reduces the severity of pyridostigmine.