Hydrea costs

Synonyms:
Hydroxycarbamide, Gidrea, hydroxyurea, Hydroxycarbamide Medak, Gidroksiurea, Litalir, Oksikarbamid, Biosupressin, Hydrea, Hydroxycarbamide, Hidrix, Hydroxycarbamidum, Nudura, Litaliz, Onco-carbamidi.
Description

Active ingredient – Hydroxycarbamide, oksiproizvodnoe urea.
Pharmacological action

Cytostatics. Causes a delay in DNA synthesis without affecting the synthesis of RNA or protein. Believed what antimetabolicheskoe selective effect due to violation of enzymatic conversion of ribonukleidov dezoksiribonukleotidy, vozmozhno delayed entry of thymidine into DNA.
Indications for use

The main indications are chronic myelogenous leukemia and true politsitemiya.
Dosing and Administration

Capsules are taken before meals with a small amount of liquid. In chronic myeloid leukemia determined by high dose hydroxyurea leukocytosis and may vary from 6 capsules a day to 1 capsule 2-3 times a week. The usual daily dose of 30-50 mg / kg maccy with uchetom white blood cell count: at hyperskeocytosis 150 000-200 000 and above can be given 4-6 capsules per day (2000-3000 mg), while the number of leukocytes 50 000-100 000 enough 2-3 capsules per day (1000-1500 mg), leukocytosis in 20 000-30 000, you can use 1-2 capsules per day. In the normal number of leukocytes or nebolshom leukocytosis (15 000-20 000 in 1 mm3) can be assigned to maintenance dose is 1 capsule a day or 2 times a week.

When erythremia (true politsitemii) gidrea prescribe a dose of 500 to 2000 mg per day until the normalization of blood parameters. After achieving remission – maintenance therapy with 500 mg daily continuously.
Side effects

The most common sign of toxicity after prolonged use of high doses of hydroxyurea is bone marrow depression, manifested kotopaya neytrotsitopeniey. Possible atrophic dermatitis, maculopapular rash, and even partial alopecia. In some clychayah a slight fever, stomatitis, dizziness and headache.
Contraindications

Increased sensitivity to gidrea, leykotsitopeniya (less than 3000/mm3), thrombocytopenia (less than 100 000/mm3), pregnancy and lactation.
Interaction

Increases the effect of cytarabine, weakens – 5-fluorouracil and methotrexate. Increases (mutually) myelotoxicity of drugs depressing the function of bone marrow. The risk of developing nephropathy increases with a joint appointment with urikozuricheskimi means. In combination with antidepressants, antihistamines, sedatives, hypnotics, narcotic drugs and alcohol increases the inhibition of the reaction rate.
Cautions

Caution must be exercised in the appointment of the elderly and children, patients, wherewith previously held radiation or cytostatic therapy. Before treatment shows a deep correction of anemia. In the course of treatment requires regular blood tests. Recommended takzhe dynamic control ypovnem uric acid, creatinine, transaminases. During treatment, patients should drink plenty of fluids.